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KMID : 0615720090260020031
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Jouranl of Korean Acupuncture and Moxibustion society
2009 Volume.26 No. 2 p.31 ~ p.40
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Effects of Daedon(LR1) Supplementation and Eumgok(KI10) Draining on Changes of Cerebral Hemodynamics in Normal Rats
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Jung Ho-Seok
Ryu Chung-Ryul
Cho Myoung-Rae
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Abstract
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Objectives: The purpose of this study is to investigate the effects of Daedon(LR1) Supplementation and Eumgok(KI10) Draining on changes of cerebral blood flow in normal rats.
Methods: Regional cerebral blood flow(rCBF) and mean arterial blood pressure(MABP) in normal rats are observed, and those mechanisms were also investigated with pre-treatment of indomethacin (IDM) and methylene blue(MTB) each.
Results: In this study, LR1 supplementation and KI10 draining elevated level of rCBF after 30 min, but MABP level was lowered at 30 min, then recovered toward normal level. Pre-treatment with indomethacin(IDM), an inhibitor of cyclooxygenase, inhibited increase of rCBF effectively, and pre-treatment with methylene blue(MTB), an inhibitor of guanylate cyclase, also inhibited increase of rCBF levels. On the other hand pre-treatment with IDM or MTB did not affect MABP levels.
Conclusions: In conclusion, these results suggest that LR1 supplementation and KI10 draining can increase rCBF, and the mechanisms are thought to be related to both of cyclooxygenase and Guanylate cyclase pathways.
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KEYWORD
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LR1 supplementation and KI10 draining in acupuncture, Regional cerebral blood flow (rCBF), Mean arterial blood pressure(MABP), Cyclooxygenase pathway, Guanylate cyclase pathway
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